Personalized Medicine & Dietary Supplementation
Cannabis therapeutics is personalized medicine. The right treatment regimen depends on the person and condition being treated. For maximum therapeutic benefit, choose cannabis products that include both cannabidiol (CBD), a non-intoxicating compound, and tetrahydrocannabinol (THC) 0.3%, the psychoactive component of cannabis depending on the condition treated. CBD and THC interact to enhance each other’s therapeutic effects. They work best together. A patient’s sensitivity to THC is a key factor to determining the ratio and dosage of CBD-rich medicine. For dietary supplementation the maximum THC concentration in a full spectrum CBD oil is usually 0.3% for an optimum therapeutic effect and also as a daily supplement.
Many people enjoy the cannabis high and can consume reasonable doses of any cannabis product without feeling too high or dysphoric that’s why 0.3% THC by dry weight is the established (Federal Legal Limit). Others find THC unpleasant. CBD can lessen or neutralize the intoxicating effects of THC. So a greater ratio of CBD-to-THC means less of a “high.” studies have shown that ingesting Full Spectrum CBD can cause confirmed positive results when screening urine and blood specimens.
Finding your ratio is the first step to effective treatment.
Find Your Ratio!
General dosage guide
CBD is most commonly taken orally as drops/tincture format under the tongue. Below are some general CBD dosage guidelines:
- General Health: 2.5-15mg CBD by mouth daily
- To treat chronic pain: 2.5-20 mg CBD by mouth daily
- To treat sleep disorders: 40-160 mg CBD by mouth daily
Although banned by federal law, dosed cannabis medicine is currently available in the form of concentrated oil extracts, infused sublingual sprays, capsules, edibles, and other products. Potent cannabis oil extracts have varying ratios of CBD and THC that are calibrated to suit the needs and sensitivities of each patient.
For anxiety, depression, spasms, and pediatric seizure disorders, many patients initially find they do best with a moderate dose of a CBD-dominant remedy (a CBD:THC ratio of more than 10:1). But a low THC remedy, while not intoxicating, is not necessarily the best therapeutic option. A combination of CBD and THC will likely have a greater therapeutic effect for a wider range of conditions than CBD or THC alone. For cancer, neurological disease, and many other ailments, patients may benefit from a balanced ratio of CBD and THC. Extensive clinical research has shown that a 1:1 CBD:THC ratio is effective for neuropathic pain. Optimizing one’s therapeutic use of cannabis may entail a careful, step-by-step process, whereby a patient starts with small doses of a non-intoxicating CBD-rich remedy, observes the results, and gradually increases the amount of THC.
In essence, the goal is to self-administer consistent, measurable doses of a CBD-rich remedy that includes as much THC as a person is comfortable with.
The Biphasic Effect
Cannabis compounds have biphasic properties, which means that low and high doses of the same substance can produce opposite effects. Small doses of cannabis tend to stimulate; large doses sedate. Too much THC, while not lethal, can amplify anxiety and mood disorders. CBD has no known adverse side effects at any dose, but drug interactions can be problematic. An excessive amount of CBD could be less effective therapeutically than a moderate dose. “Less is more” is often the case with respect to cannabis therapy.
“Dosage is everything”—Paracelsus
How Much CBD Oil Should I Take?
- Decide how you want to take cannabis. Cannabis oil is available in sprays, capsules, edibles and other products.
- Find your ratio. Cannabis products have varying amounts of CBD and THC. A high CBD or high THCproduct is not necessarily superior to a strain with a balanced ratio. Find the proper combination to optimize your therapeutic use of cannabis.
- Begin with a low dose especially if you have little or no experience with cannabis.
- Take a few small doses over the course of the day rather than one big dose.
- Use the same dose and ratio for several days. Observe the effects and if necessary adjust the ratio or amount.
- Don’t overdo it. “Less is more” is often the case with cannabis therapeutics.
- Be aware of possible side effects. Cannabis is a safe and forgiving medicine. Depending upon delivery method and individual tolerance, it can amplify anxiety and mood disorders. Other possible side effects are dry mouth, dizziness and faintness.
- To increase appetite in cancer patients: 2.5 milligrams of THC by mouth with or without 1 mg of CBD for six weeks
- To treat chronic pain: 2.5-20 mg CBD by mouth for an average of 25 days.
- To treat epilepsy: 200-300 mg of CBD by mouth daily.
- To treat movement problems associated with Huntington’s disease: 10 mg per kilogram of CBD by mouth daily for six weeks.
- To treat sleep disorders: 40-160 mg CBD by mouth.
- To treat multiple sclerosis symptoms: Cannabis plant extracts containing 2.5-120 milligrams of a THC-CBD combination by mouth daily for 2-15 weeks. A mouth spray might contain 2.7 milligrams of THC and 2.5 milligrams of CBD at doses of 2.5-120 milligram for up to eight weeks. Patients typically use eight sprays within any three hours, with a maximum of 48 sprays in any 24-hour period.
- To treat schizophrenia: 40-1,280 mg CBD by mouth daily.
- To treat glaucoma: a single CBD dose of 20-40 mg under the tongue. Doses greater than 40 mg may actually increase eye pressure.
- Consult your health counselor. Proceed cautiously, especially if you have a history of alcohol or drug abuse, mental illness, or are pregnant or breastfeeding.
According to CannLabs, the nation’s top full-service testing lab for cannabis products, there is no established lethal CBD dose. Consumers should read product inserts carefully to ensure they are taking the right amount of CBD, and talk to the prescribing physician about any questions or concerns.